Rudhra Joshi .

Hey, I'm Rudhra Joshi.

MS in Bioinformatics & Bachelor's in Pharmacy

Bioinformatics Researcher with 5+ years of experience specializing in chromatin conformation analysis (Hi-C, HiChIP, ChIA-PET) and deep learning for genomics. Developed Chr3D chromatin analysis framework and built open-source implementations of 20+ SOTA models including AlphaFold, CLIP, and diffusion architectures.

Bioinformatics | Medicinal Chemistry | Molecular Docking | Machine Learning | Deep Learning | RNA-seq | Hi-C | ChIP-seq | ATAC-seq | ChIA-PET | HiChIP | GATK | Pharmaceutical Science |
Bioinformatics | Medicinal Chemistry | Molecular Docking | Machine Learning | Deep Learning | RNA-seq | Hi-C | ChIP-seq | ATAC-seq | ChIA-PET | HiChIP | GATK | Pharmaceutical Science |

Research Experience

Chromatin 3D Analysis Research

Rowan University — Dr. Yong Chen's Lab
Sep 2024 – Present
Hi-C
ChIA-PET
HiChIP
Deep Learning
Python
Chromatin Biology

Analyzed 20+ TB of chromatin conformation capture (3C) data. Developed Chr3D, a standardized Python framework for comprehensive 3C technique analysis. Built transformer-based deep learning model for Hi-C coverage enhancement. Contributing to manuscript on chromatin 3D structure prediction methods.

Radio Signal Deep Learning Research

Rutgers & Rowan University — Dr. Silvija Kokalj-Filipovic Lab
Oct 2025 – Present
PointMAE
CLIP
Diffusion Models
H100 GPU
Sionna
3D Point Cloud

Trained PointMAE model from scratch on 8+ H100 Nvidia GPU cluster. Fine-tuned deep learning models for 3D spatial embeddings in radio signal propagation. Developed CLIP-based multimodal models and diffusion architectures for 3D scene understanding.

Triple-Negative Breast Cancer Drug Design

ITM University — Prof Ankita Tarapara
Oct 2022 – 2024
Medicinal Chemistry
RDKit
Autodock
HPLC
Drug Synthesis

Secured ₹1,20,000 SSIP Hub grant for synthesis and formulation targeting TNBC. Designed lead molecule library using RDKit and performed molecular docking on BRCA proteins. Conducted SAR analysis and wet lab characterization including HPLC and TLC.

The Bioinformatics Arsenal

Open Source — 20+ SOTA Models
2023 – Present
AlphaFold
ESM-2
DNABERT
PyTorch
Transformers
Evoformer

Reimplemented 20+ SOTA deep learning papers from scratch including AlphaFold 2/3, ESM-2 (650M parameters), and DNABERT. Created detailed documentation with architecture visualizations. Trained models at scale on 8+ H100 GPU Nvidia Brev cluster.

Genome Studio

Full Stack Bioinformatics Platform
2023 – Present
Next.js
FastAPI
LangChain
AWS
No-Code
Pipeline Builder

Built no-code bioinformatics platform with drag-and-drop graph-based interface. Engineered dependency resolution system supporting R, Python, and Bash workflows. Implemented LangChain-powered LLM integration for automated code generation.

Chr3D Framework

Novel Chromatin Analysis Tool
2024 – Present
Python
Hi-C
Statistical Methods
Scipy
Chromatin Loops

Developed Chr3D, a comprehensive Python framework for chromatin interactions analysis with integrated statistical methods. Manuscript in preparation for expected submission March 2026.

CLIP Knowledge Model

Interactive 3D visualization of CLIP embeddings showing how the model organizes visual and textual concepts in a shared embedding space. Explore 100 classes with 3000 image and text embeddings. View on GitHub

Click on dots it will show you the embeddings of the class and images representing that embeddings

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Skills and Hobbies

#1 Programming Languages

  • Python
  • Javascript
  • Typescript
  • Node.js
  • Julia
  • React.js
  • C++
  • C
  • Tailwind CSS
  • Slate.js
  • Framer Motion
  • Bash
  • PyTorch

#2 Frameworks & Open Source

  • Next.js
  • Blender
  • Remix.js
  • Redhat
  • CCNA
  • AWS
  • Docker
  • Google Cloud Service
  • Github
  • System Design
  • Firebase Firestore
  • Google Cloud Storage
  • Flutter
  • Pub/Sub
  • Microsoft Excel
  • Microsoft Word
  • Pandas
  • Numpy
  • Sklearn
  • ec2
  • s3
  • MiniIO
  • Nginx
  • CI/CD
  • Fast AI
  • MongoDB
  • Vercel
  • Shadcn UI

#3 Sequencing & Omics

  • RNA-seq
  • ChIP-seq
  • Hi-C Seq
  • ChIA-PET
  • HiChIP
  • DESeq2
  • Variant Analysis
  • Scanpy
  • Single-cell Analysis
  • Multi-omics Analysis
  • Pipeline Development
  • Statistical Analysis
  • Chr3D
  • Various Databases (Promoter/Enhancer, ClinVar)

#4 Drug Discovery Tools

  • RDKit
  • Autodock
  • Autodock Vina
  • rDock
  • Pymol
  • Discovery Studio
  • Chemdraw 3d
  • Sorcery Dock
  • Open Babel API
  • Dataset Filteration
  • Schrodinger
  • Molecular Docking

#5 Deep Learning & AI Architectures

  • Attention Architecture (All Variants)
  • CNN
  • Diffusion (Flow Matching)
  • AE/VAE
  • UNET
  • Hyena
  • Transformers
  • Evoformer
  • CLIP Architecture
  • BERT
  • HyenaDNA
  • AlphaFold 2/3
  • ESM-2
  • Chai-1
  • DNABERT
  • Reinforcement Learning
  • 21+ Reimplementation of Bioinformatics Models
  • PointMAE Finetuning
  • Experience Training on 8x A100 GPUs
  • LangChain RAG System
  • Ollama
  • Genomic Data Processing
  • Feature Extraction

#6 Pharmaceutical Science

  • Pharmaceutics 1/2/3
  • Pharmacology 1/2/3
  • Medicinal Chemistry 1/2/3
  • Pharmacognosy 1/2/3
  • Organic Chemistry 1/2
  • Inorganic Chemistry 1/2
  • Microbiology

#7 Books

  • The 4 Hours Work Week
  • Elon Musk - Ashlee Vance
  • The Warren Buffett Way
  • Outliers
  • Influence
  • Zero to One
  • Think and Grow Rich
  • The One Thing
  • Start With Why
  • Ikigai
  • Rich Dad Poor Dad
  • 7 Secrets of Persuasion
  • The Art of Thinking Clearly
  • Eat That Frog
  • How to Win Friends and Influence People
  • The Psychology of Money
  • The Compound Effect
  • The New One Minute Manager
  • The Leader In You
  • The Power of Your Subconscious Mind
  • Never Split the Difference
  • How to Talk to Anyone
  • Deep Work
  • Instant Self-Hypnosis

Latest Blog Posts

Understanding Molecular Evolution

Exploring evolutionary changes at the molecular level with an emphasis on genetic and protein modifications, including practical bioinformatics applications in phylogenetics and molecular clock theory.

Bioinformatics
Evolution
Genetics
8/12/2024
10 min

Drug Discovery Basics

An introduction to computational drug discovery techniques, covering key methods like molecular docking, QSAR, and ligand-based virtual screening. Ideal for bioinformaticians entering pharmacoinformatics.

Drug Discovery
Computational Biology
Pharmacoinformatics
6/24/2024
8 min

Single-Cell Sequencing in Cancer Research

A deep dive into the role of scRNA-seq in cancer studies, focusing on its applications for tumor heterogeneity and precision medicine.

Cancer Research
Single-Cell Analysis
Genomics
5/15/2024
12 min

Data Acquisition in Bioinformatics

Overview of efficient methods for acquiring datasets in bioinformatics, including resources like NCBI, GenBank, and EMBL, with a focus on open-source data for large-scale analyses.

Data Science
Bioinformatics
Data Acquisition
3/20/2024
7 min

EADock: Evolutionary Algorithms for Molecular Docking

Explains the EADock algorithm and its role in docking small molecules into protein active sites using multiobjective evolutionary optimization, highlighting its utility in structure-based drug design.

Molecular Docking
Drug Design
Evolutionary Algorithms
1/28/2024
15 min

TeachOpenCADD: Computer-Aided Drug Design with Python

A guide to using the TeachOpenCADD library for computational drug design in Python, covering core techniques like molecular modeling, docking, and cheminformatics applications.

Drug Design
Python
Open Source
11/2/2023
11 min